Aggregation of gel-filtrated platelets induced by thrombospondin.
نویسندگان
چکیده
منابع مشابه
Thrombospondin-induced adhesion of human platelets.
Washed human unactivated platelets attached and spread on thrombospondin (TSP)-coated microtiter plates. Platelet adhesion was promoted by divalent cations Mn2+, Mg2+, and Ca2+ as compared to buffer having all divalent cations complexed with EDTA. TSP-dependent adhesion was inhibited by anti-TSP fab fragments, an anti-TSP monoclonal antibody, an RGD-containing peptide, complex-specific anti-gly...
متن کاملDeficiency of Intact Thrombospondin and Membrane Glycoprotein La in Platelets With Defective Collagen - Induced Aggregation
Platelets from a patient with a severe lifelong bleeding tendency. which later spontaneously disappeared, lacked intact thrombospondin and glycoprotein (GP) Ia. Before disappearance of the bleeding disorder, results of coagulation studies and platelet aggregation in response to adenosine diphsophate (ADP). arachidonic acid. thrombin. A231 87, epinephrine. and ristocetin were normal. In contrast...
متن کاملDeficiency of Intact Thrombospondin and Membrane Glycoprotein La in Platelets With Defective Collagen - Induced Aggregation and Spontaneous Loss of Disorder
Platelets from a patient with a severe lifelong bleeding tendency. which later spontaneously disappeared, lacked intact thrombospondin and glycoprotein (GP) Ia. Before disappearance of the bleeding disorder, results of coagulation studies and platelet aggregation in response to adenosine diphsophate (ADP). arachidonic acid. thrombin. A231 87, epinephrine. and ristocetin were normal. In contrast...
متن کاملThrombospondin promotes platelet aggregation.
Thrombospondin (TSP), isolated from human platelets, promotes aggregation of both nonstimulated platelets and platelets stimulated with thrombin or ADP. The TSP-promoted aggregation is specific since a monoclonal antibody against TSP inhibits the effect of exogenously added TSP and inhibits thrombin-induced platelet aggregation in the absence of added TSP. Several lines of evidence suggest that...
متن کاملDeficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder.
Platelets from a patient with a severe lifelong bleeding tendency, which later spontaneously disappeared, lacked intact thrombospondin and glycoprotein (GP) Ia. Before disappearance of the bleeding disorder, results of coagulation studies and platelet aggregation in response to adenosine diphosphate (ADP), arachidonic acid, thrombin, A23187, epinephrine, and ristocetin were normal. In contrast,...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1987
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.18.70